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Diabetes, Vol 24, Issue 12 1081-1085, Copyright © 1975 by American Diabetes Association

ARTICLES

Fast and slow axoplasmic flow in sciatic nerve of diabetic rats

RE Schmidt, FM Matschinsky, DA Godfrey, AD Williams and DB McDougal

Accumulation of acetylcholinesterase (AChE) and choline acetylase (ChAc) activities proximal to a tie placed on the sciatic nerve was measured in control, untreated diabetic, and insulin-treated diabetic rats. In the diabetic animals AChE accumulation was reduced by about 20% and ChAc accumulation by about 40%. Insulin treatment eliminated the impairment. It remains an open question whether these reversible functional changes in rat have any counterpart in the diabetic neuropathy of man.
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Copyright © 1975 by the American Diabetes Association.