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Diabetes, Vol 24, Issue 7 618-624, Copyright © 1975 by American Diabetes Association

ARTICLES

Effect of phenformin on gluconeogenesis from lactate and intracellular pH in the isolated perfused guinea pig liver

MH Lloyd, RA Iles, B Walton, CA Hamilton and RD Cohen

Gluconeogenesis from lactate and hepatic cell pH (pHi) were measured in the isolated perfused livers of starved guinea pigs in the presence and absence of phenformin (phenethylbiguanide). The observed decrease in lactate consumption and glucose output in the presence of phenformin was associated with a fall in pHi. The fall in glucose output observed was considerably greater than accountable for by the decrease in lactate consumption. A possible mechanism for the pathogenesis of clinical lactic acidosis due to phenformin therapy is suggested.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1975 by the American Diabetes Association.