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Diabetes, Vol 24, Issue 7 684-687, Copyright © 1975 by American Diabetes Association

ARTICLES

Inhibition of labile aggregation-stimulating substance (LASS) and platelet aggregation in diabetes mellitus

JA Colwell, A Chambers and M Laimins

Irreversible second-phase aggregation of platelets in diabetic patients is prevented in vitro by 5, 8, 11, 14-eicosatetraynoic acid (TYA), a competitive inhibitor of the labile aggregation-stimulating substance (LASS) which is formed from arachidonic acid. Thus, inhibition of prostaglandin synthesis inhibits platelet aggregation in diabetic subjects. These findings indicate that platelets from diabetics are subject to control by intracellular mechanisms operative in the regulation of platelet function in normal individuals.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1975 by the American Diabetes Association.