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Diabetes, Vol 25, Issue 12 1106-1109, Copyright © 1976 by American Diabetes Association

ARTICLES

Leucocyte-migration inhibition induced by uveoretinal antigen in patients with diabetic retinopathy

Z Aviner, WL Henley, S Okas and IH Leopold

Leucocyte-migration inhibition was to determine the state of hypersensitivity in 65 diabetic patients with different stages of retinopathy and 21 nondiabetic controls. About one third of the patients with simple or proliferative retinopathy exhibited significant leucocyte-migration inhibition of 0.2 mg/ml. protein concentration of uvreoretinal antigen. In contrast, only one of 15 patients with minimal retinopathy and none of the controls showed significant leucocyte-migration inhibition. Corneal and lenticular antigens did not evoke a cellular immune response in any of the tested individuals. These findings suggest that cell-mediated hypersensitivity to uveoretinal antigen may develop in diabetic patients with prolonged, progressive, simple or proliferative retinopathy.
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Copyright © 1976 by the American Diabetes Association.