Diabetes, Vol 26, Issue 5 453-465, Copyright © 1977 by American Diabetes Association
The prognostic importance of plasma glucose levels and of the use of oral hypoglycemic drugs after myocardial infarction in men
The relationship of plasma glucose levels to risk of death over a five-year
follow-up period was studied in 2,770 male survivors of myocardial
infarction in the placebo group of the Coronary Drug Project (CDP). In
univariate analyses, a positive association was observed between mortality
rates and both fasting and one-hour glucose levels. After adjustment for 38
other baseline characteristics, the strengths of these relationship were
substantially diminished; however, an increased mortality persisted in
patients with fasting glucose levels larger than or equal to 140 mg./dl.
after adjustment for other risk variables. There exists some evidence of an
increased mortality risk in users of oral hypoglycemic (OH) agents over
that of nonusers at baseline in men with elevated baseline glucose levels.
However, the results must be interpreted with great caution both because
they are of only borderline statistical significance and also because
various factors not recorded in the CDP might have influenced the results.
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