Diabetes, Vol 27, Issue 5 592-596, Copyright © 1978 by American Diabetes Association

ARTICLES

Multiple daily insulin injections in the treatment of diabetic retinopathy. The Job study revisited

T Ashikaga, G Borodic and EA Sims

Data based on the prospective study of Job et al. are reanalyzed while initial number of microaneurysms and duration of patient follow-up are controlled. The reported statistical difference in the rate of microaneurysm increase between the single- and the multiple-daily-injection groups may be due to a difference in a subgroup who had a larger number of microaneurysms initially and who were studied for a shorter period of time. No uniform difference was observed in the results of their treatment between the groups given a single injection and those given multiple injections. While this does not invalidate the conclusions of the study, it does point out the need for greater control in conducting future studies.
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