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Diabetes, Vol 27, Issue 5 597-598, Copyright © 1978 by American Diabetes Association

ARTICLES

Synthetic fragment of human growth hormone with hyperglycemic properties: residues 44-77

AJ Lostroh and ME Krahl

Peptides homologous to Cys53 44-77 and Cys53 52-77 of the human growth hormone molecule were prepared by solid-phase synthesis and tested by our acute glucose tolerance test in ob/ob mice. Peptide 44-77, as either the Acm-Cys53 or Cam-Cys53 derivative, adversely affects glucose tolerance at doses of 100 to 150 nmol. Peptide 52-77 is nonhyperglycemic. Other diabetogenic properties are being tested.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1978 by the American Diabetes Association.