Diabetes, Vol 28, Issue 1 65-70, Copyright © 1979 by American Diabetes Association
Regranulation of islets of Langerhans and normalization of in vivo insulin secretion in ob/ob mice treated with oxytetracycline
N Begin-Heick, HM Heick and MG Norman
Oxytetracycline (OTC) treatment was associated with regranulation of the islet cells and increased pancreatic insulin content in the ob/ob mouse. This was accompanied by an improvement of the in vivo insulin secretory response to glucose. Because of the wide-ranging effects of OTC on other membrane-related functions, it is postulated that this compound may exert ist effect by altering the composition of cellular membranes.
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