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Diabetes, Vol 29, Issue 1 37-40, Copyright © 1980 by American Diabetes Association

ARTICLES

One month of sustained release of insulin from a polymer implant

HM Creque, R Langer and J Folkman

Rats made diabetic with streptozotocin received a single subcutaneous implant of an insulin polymer pellet that released insulin continuously at approximately 2 U/day. Continuous normoglycemia was achieved for up to 1 mo. Mean glucose level for treated animals was 113 mg/dl as compared with 398 mg/dl for untreated diabetic controls. Diurnal blood glucose values for treated animals ranged from 71 to 116 mg/dl. Polyuria and glycosuria were corrected by the presence of the insulin + polymer. Treated animals gained weight normally and reached a mean weight of 350 g, whereas untreated control animals lost weight, to a mean of 150 g. When insulin + polymer preparations were periodically implanted and removed at 7-day intervals, normoglycemia was only associated with the presence of implants.
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This article has been cited by other articles:


Home page
 Journal of Bioactive and Compatible PolymersHome page
B. Buntner, M. Nowak, M. Bero, P. Dobrzyiiski, and J. Kasperczyk
Controlled Release of 17{beta}-Estradiol from d,l-Lactide/{epsilon}-Caprolactone Copolymers
Journal of Bioactive and Compatible Polymers, April 1, 1996; 11(2): 110 - 121.
[Abstract]


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Copyright © 1980 by the American Diabetes Association.