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Diabetes, Vol 29, Issue 1 84-86, Copyright © 1980 by American Diabetes Association

ARTICLES

Disparate effects of enkephalin and morphine upon insulin and glucagon secretion by islet cell cultures

RA Kanter, JW Ensinck and WY Fujimoto

Insulin and glucagon release from monolayer pancreatic islet cell cultures were inhibited in a dose-response fashion by various enkephalins. Morphine, however, stimulated insulin and glucagon release. Both effects were blocked by naloxone, while naloxone alone had no effect. In isolated and denervated islet cells, opiates directly influence secretion from islet cells.
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D. A. Jacobson, J. Cho, L. R. Landa Jr., N. A. Tamarina, M. W. Roe, J. D. Buxbaum, and L. H. Philipson
Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E587 - E595.
[Abstract] [Full Text] [PDF]


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Copyright © 1980 by the American Diabetes Association.