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Diabetes, Vol 29, Issue 2 156-158, Copyright © 1980 by American Diabetes Association

ARTICLES

Transformation of glicentin-containing L-cells into glucagon-containing cells by enzymatic digestion

M Ravazzola and L Orci

Exposure of sections of ileal mucosa to enzymatic digestion with trypsin and carboxypeptidase B reveals a population of immunofluorescent cells after incubation with a specific C-terminally directed antiglucagon serum. These cells, unreactive before enzyme treatment, were identified as L-cells by their immunoreactivity to antiglicentin serum and to cross-reacting (N-terminal) antiglucagon sera. The presence in the L-cells of antigenic sites characteristic of the glucagon-containing cells (A-cells) emphasizes the close relationships between these two cell types, and it further supports the hypothesis of glicentin as a glucagon precursor.
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Copyright © 1980 by the American Diabetes Association.