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Diabetes, Vol 29, Issue 2 164-166, Copyright © 1980 by American Diabetes Association


ARTICLES

Influence of the age of erythrocytes on their insulin receptors

J Eng, L Lee and RS Yalow

Specific binding of 125I-insulin to erythrocyte receptors increased linearly with reticulocyte count in routine blood specimens from hospitalized patients. Specific binding as high as 30-35% is observed in patients with reticulocyte counts in the range of 20-25% compared with 9.0 +/- 0.5% specific binding in healthy control subjects with normal reticulocyte counts. It is concluded that care must be exercised in interpreting elevations of specific 125I-insulin binding to erythrocyte receptors as due to specific disease processes without considering how the disease itself may alter mean erythrocyte age at the time of sampling.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1980 by the American Diabetes Association.