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Diabetes, Vol 29, Issue 4 292-295, Copyright © 1980 by American Diabetes Association

ARTICLES

Effects of insulin and pancreatic polypeptide on gastric somatostatin release

T Chiba, T Taminato, S Kadowaki, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino and T Fujita

Effects of arginine and such pancreatic hormones as insulin and pancreatic polypeptide on gastric somatostatin release from the isolated perfused rat stomach were studied. The stomach was isolated from a fasted rat by a modification of the method of Lefebvre and was perfused with 4.6% dextran Krebs-Ringer biocarbonate buffer containing 5.5 mM glucose. Both insulin and pancreatic polypeptide (10(-10), 10(-9), and 10(-8) M) caused a significant decrease in gastric somatostatin secretion. Insulin (10(-10) M), furthermore, inhibited the glucagon (5 x 10(-8) M)-induced somatostatin response. Arginine (10 and 19 mM) failed to elicit any significant change of somatostatin release. These results suggest that gastric somatostatin release is affected by pancreatic hormones.
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