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Diabetes, Vol 29, Issue 8 659-661, Copyright © 1980 by American Diabetes Association

ARTICLES

Studies on the insulin mediator. II. Separation of two antagonistic biologically active materials from fraction II

K Cheng, G Galasko, L Huang, J Kellogg and J Larner

Insulin treatment significantly altered the elution profile of deproteinized muscle extracts chromatographed on Sephadex G-25 columns, particularly in fraction II, which contains the insulin mediator. Further purification of fraction II by high-voltage paper electrophoresis at pH 1.9 and 3.5 resulted in two active fractions. Fraction 1 leads to 4 stimulated the cyclic AMP-dependent protein kinase and inhibited glycogen synthase phosphoprotein phosphatase, and may be a novel substance. Fractions 1 leads to 6 and 3 leads to 6 inhibited the cyclic AMP-dependent protein kinase and stimulated glycogen synthase phosphatase. It is proposed that the insulin mediator is present in fractions 1 leads to 6 and 3 leads to 6.
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K Hanif, K Lederis, M. Hollenberg, and H. Goren
Inability of oxytocin to activate pyruvate dehydrogenase in the Brattleboro rat
Science, May 28, 1982; 216(4549): 1010 - 1012.
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Copyright © 1980 by the American Diabetes Association.