Diabetes, Vol 30, Issue 10 879-882, Copyright © 1981 by American Diabetes Association
Demonstration of glucagon in the stomach of human fetuses
M Ravazzola, RH Unger and L Orci
Electron microscopy using antiglucagon or antiglicentin antisera and the protein A-gold (pAg) technique revealed a population of immunoreactive cells in the gastric mucosa of human fetuses. The secretory granules of these cells showed the same ultrastructural characteristics and the same labeling pattern as pancreatic alpha-granules. These data demonstrate that the stomach of human fetuses contains cells with secretory granules indistinguishable by morphologic and immunocytochemical criteria from the pancreatic A-cells.
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