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Diabetes, Vol 30, Issue 11 907-910, Copyright © 1981 by American Diabetes Association

ARTICLES

Acetylator phenotypes and type I (insulin-dependent) diabetics with microvascular disease

HJ Bodansky, PL Drury, AG Cudworth and DA Evans

We have investigated the acetylator dimorphism in 55 type I (insulin-dependent) diabetics. The frequency of the fast phenotype (49%) was higher than in the general Northern European population (37%). Although this difference was not significant (chi squared = 2.64, P = 0.1) the combination of our data with data from two other studies produced a significant positive association between the fast acetylator phenotype and type I diabetes (P = 0.00013, relative risk = 2.0). These findings lend support to the concept that more than one genetic locus may be involved in the susceptibility to type I diabetes. No association was found between acetylator phenotypes and diabetic complications.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1981 by the American Diabetes Association.