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Diabetes, Vol 30, Issue 12 1065-1067, Copyright © 1981 by American Diabetes Association

ARTICLES

Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate

T Nishihata, JH Rytting, A Kamada and T Higuchi

Sodium 5-methoxysalicylate, previously shown to enhance the rectal absorption of several drugs, facilitates the absorption of insulin from the upper gastrointestinal tract, resulting in significantly elevated insulin levels and lowered glucose concentrations in the plasma of rats. Restricting the movement of insulin and adjuvant down the intestine by either ligation or use of a more viscous vehicle further increased the absorption of insulin.
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Concept, Strategies, and Feasibility of Noninvasive Insulin Delivery
Diabetes Care, January 1, 2004; 27(1): 239 - 246.
[Abstract] [Full Text] [PDF]


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Copyright © 1981 by the American Diabetes Association.