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Diabetes, Vol 30, Issue 3 188-191, Copyright © 1981 by American Diabetes Association

ARTICLES

Concentration and secretion of gastric somatostatin in streptozotocin-diabetic rats

T Chiba, S Kadowaki, T Taminato, H Abe, K Chihara, S Matsukura, Y Goto, Y Seino and T Fujita

Both the release and the content of gastric somatostatin were investigated in streptozotocin-diabetic rats. Fundic and antral somatostatin contents were both increased in streptozotocin-diabetic rats compared with control animals. Basal somatostatin levels in the perfusates of streptozotocin-treated animals were not significantly different from those of the control animals. However, the peak values of somatostatin release induced by 5 x 10(-9) M glucagon in the diabetic animals were significantly higher than those of the controls. These results lead us to conclude that a hyperfunctioning state of the gastric D-Cells exists in hypoinsulinemic diabetes.
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Y.-C. Lu, C. Sternini, E. Rozengurt, and E. Zhukova
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[Abstract] [Full Text] [PDF]


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Copyright © 1981 by the American Diabetes Association.