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Diabetes, Vol 33, Issue 5 435-437, Copyright © 1984 by American Diabetes Association

ARTICLES

Pancreatic alpha cell autoantibodies and glucagon response to arginine

WE Winter, NK Maclaren, WJ Riley, RH Unger, M Neufeld and PT Ozand

The frequency and significance of cytoplasmic pancreatic alpha cell autoantibodies (ACA) were investigated in 2102 healthy controls, 879 patients with insulin-dependent diabetes mellitus (IDDM) who were negative for islet cell autoantibodies (ICA), and 1567 relatives of IDDM patients. ACA were found in approximately 1 in 200 people of all ages and were not significantly associated with IDDM, the IDDM-associated HLA phenotypes DR3 and DR4, or thyrogastric or adrenal autoantibodies. Of 11 ACA-positive patients studied by arginine stimulation tests, none had frank glucagon deficiency. Thus, ACA do not appear to be associated with defective alpha cell function or with IDDM.
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This article has been cited by other articles:


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A. L. Lethagen, U.-B. Ericsson, B. Hallengren, L. Groop, and T. Tuomi
Glutamic Acid Decarboxylase Antibody Positivity Is Associated with an Impaired Insulin Response to Glucose and Arginine in Nondiabetic Patients with Autoimmune Thyroiditis
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1177 - 1183.
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Copyright © 1984 by the American Diabetes Association.