Diabetes, Vol 34, Issue 1 74-78, Copyright © 1985 by American Diabetes Association

ARTICLES

The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats

DK Yue, S McLennan, DJ Handelsman, L Delbridge, T Reeve and JR Turtle

The importance of cyclooxygenase and lipoxygenase pathways in the determination of collagen abnormalities in diabetes was investigated. Pharmacological agents with antiprostaglandin activity, such as indomethacin, naproxen, and aspirin, were able to prevent the rise in thermal rupture time of tail collagen in diabetic rats. Paracetamol was without effect. The action of indomethacin on diabetic collagen was abolished by concurrent administration of sodium benoxaprofen, an inhibitor of lipoxygenase, to the diabetic rats. Collagen abnormalities in diabetes may be regulated by a balance of the cyclooxygenase and lipoxygenase pathways. Antiprostaglandin agents may have a role in the prevention of some diabetic complications.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Bavbek, A. Kargili, O. Kaftan, F. Karakurt, A. Kosar, and A. Akcay Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy? Clinical and Applied Thrombosis/Hemostasis, October 1, 2007; 13(4): 391 - 397. [Abstract] [PDF]

				Q. Mohamed, M. C. Gillies, and T. Y. Wong Management of Diabetic Retinopathy: A Systematic Review JAMA, August 22, 2007; 298(8): 902 - 916. [Abstract] [Full Text] [PDF]

				T. Kondo and C. R. Kahn Altered Insulin Signaling in Retinal Tissue in Diabetic States J. Biol. Chem., September 3, 2004; 279(36): 37997 - 38006. [Abstract] [Full Text] [PDF]

				P. Hovind, L. Tarnow, K. Rossing, P. Rossing, S. Eising, N. Larsen, C. Binder, and H.-H. Parving Decreasing Incidence of Severe Diabetic Microangiopathy in Type 1 Diabetes Diabetes Care, April 1, 2003; 26(4): 1258 - 1264. [Abstract] [Full Text] [PDF]

				M. Henricsson, K. Berntorp, P. Fernlund, and G. Sundkvist Progression of Retinopathy in Insulin-Treated Type 2 Diabetic Patients Diabetes Care, February 1, 2002; 25(2): 381 - 385. [Abstract] [Full Text] [PDF]

				Z. Pietrzyk, S. Vogel, G. J. Dietze, and S. F. Rabito Augmented Sympathetic Response to Bradykinin in the Diabetic Heart Before Autonomic Denervation Hypertension, August 1, 2000; 36(2): 208 - 214. [Abstract] [Full Text] [PDF]

				M. Lu, S. Amano, K. Miyamoto, R. Garland, K. Keough, W. Qin, and A. P. Adamis Insulin-Induced Vascular Endothelial Growth Factor Expression in Retina Invest. Ophthalmol. Vis. Sci., December 1, 1999; 40(13): 3281 - 3286. [Abstract] [Full Text] [PDF]

				F. L. Ferris, M. D. Davis, and L. M. Aiello Treatment of Diabetic Retinopathy N. Engl. J. Med., August 26, 1999; 341(9): 667 - 678. [Full Text] [PDF]

				The Diabetes Control and Complications Trial Resea Early Worsening of Diabetic Retinopathy in the Diabetes Control and Complications Trial Arch Ophthalmol, July 1, 1998; 116(7): 874 - 886. [Abstract] [Full Text] [PDF]

				A. Elgawish, M. Glomb, M. Friedlander, and V. M. Monnier Involvement of Hydrogen Peroxide in Collagen Cross-linking by High Glucose in Vitro and in Vivo J. Biol. Chem., May 31, 1996; 271(22): 12964 - 12971. [Abstract] [Full Text] [PDF]

				The Diabetes Control and Complications Trial Resea The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus N. Engl. J. Med., September 30, 1993; 329(14): 977 - 986. [Abstract] [Full Text]

				P. Reichard, B.-Y. Nilsson, and U. Rosenqvist The Effect of Long-Term Intensified Insulin Treatment on the Development of Microvascular Complications of Diabetes Mellitus N. Engl. J. Med., July 29, 1993; 329(5): 304 - 309. [Abstract] [Full Text]

				D. M. Nathan Long-Term Complications of Diabetes Mellitus N. Engl. J. Med., June 10, 1993; 328(23): 1676 - 1685. [Full Text]

				J. S. Skyler Intensive Insulin Therapy: A Personal and Historical Perspective The Diabetes Educator, January 1, 1989; 15(1): 33 - 39. [PDF]

				C. G. Hernandez The Pathophysiology of Diabetes Mellitus: An Update The Diabetes Educator, January 1, 1989; 15(2): 162 - 169. [PDF]

				J. Annahern, D. F. Kruger, P. M. Gatcomb, W. A. Petit, and W. V. Tamborlane The Diabetes Control and Complications Trial (DCCT): The Trial Coordinator Perspective: Report by the DCCT Research Group The Diabetes Educator, January 1, 1989; 15(3): 236 - 241. [PDF]