Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Begin-Heick, N.
Right arrow Articles by Heick, H. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Begin-Heick, N.
Right arrow Articles by Heick, H. M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 34, Issue 2 179-184, Copyright © 1985 by American Diabetes Association

ARTICLES

Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mouse

N Begin-Heick, M Dalpe-Scott, J Rowe and HM Heick

The purpose of this study was to establish whether a relationship may exist between the hyperinsulinemia, the exaggerated insulin secretion, and the resistance to insulin characteristic of the obese-hyperglycemic syndrome and the zinc status of the ob/ob mouse. To this end, mice were given control and zinc-supplemented diets, and the effects of zinc supplementation on insulin secretion in vivo and in vitro as well as on glucose tolerance were studied. These data were compared with those obtained with oxytetracycline treatment, which is known to ameliorate the insulin sensitivity and glucose tolerance of these animals. The levels of zinc were measured in several tissues of lean and obese mice and the results show that zinc supplementation attenuated the exaggerated insulin secretion in vivo and in vitro without improving the tolerance to glucose. Zinc levels were significantly higher in the tissues of the obese than of the lean mice, with the exception of bone and pancreas. The results suggest a maldistribution of zinc in the tissues of the obese mouse.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
R. S. Gibson, F. Yeudall, N. Drost, B. M. Mtitimuni, and T. R. Cullinan
Experiences of a Community-Based Dietary Intervention to Enhance Micronutrient Adequacy of Diets Low in Animal Source Foods and High in Phytate: A Case Study in Rural Malawian Children
J. Nutr., November 1, 2003; 133(11): 3992S - 3999.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
E. Ho, N. Quan, Y.-H. Tsai, W. Lai, and T. M. Bray
Dietary Zinc Supplementation Inhibits NF {{kappa}}B Activation and Protects Against Chemically Induced Diabetes in CD1 Mice
Experimental Biology and Medicine, February 1, 2001; 226(2): 103 - 111.
[Abstract] [Full Text]

Home page
 Exp. Biol. Med.Home page
S. F. Simon and C. G. Taylor
Dietary Zinc Supplementation Attenuates Hyperglycemia in db/db Mice
Experimental Biology and Medicine, January 1, 2001; 226(1): 43 - 51.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1985 by the American Diabetes Association.