Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yagihashi, S.
Right arrow Articles by Sima, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yagihashi, S.
Right arrow Articles by Sima, A. A.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 34, Issue 6 558-564, Copyright © 1985 by American Diabetes Association

ARTICLES

Diabetic autonomic neuropathy in the BB rat. Ultrastructural and morphometric changes in sympathetic nerves

S Yagihashi and AA Sima

Autonomic neuropathy occurring in sympathetic nerves of the spontaneously diabetic BB rat has been characterized using ultrastructural and morphometric techniques. Paravertebral thoracic ganglion cells, preganglionic myelinated fibers of the white ramus, and postganglionic unmyelinated fibers of the gray ramus communicans were examined in a longitudinal fashion. The main structural abnormality consisted of expanded axons containing a variety of normal and abnormal subcellular structures, so-called dystrophic axonal changes. These increased with duration of diabetes and were found in close proximity to the somata of ganglion cells, suggesting a preganglionic origin. The ganglion cells showed no alteration in perikaryal or nuclear volume but exhibited decreased number of synapses, which correlated with the progressive increase of dystrophic changes. While no qualitative or quantitative abnormalities could be demonstrated in preganglionic myelinated fibers of the white ramus, postganglionic fibers in the gray ramus showed an increased number of glycogenosomes, axonal sequestration, and reduction in axonal size. The present findings suggest an axonopathy in sympathetic nerves of the diabetic BB rat.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1985 by the American Diabetes Association.