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Diabetes, Vol 34, Issue 8 812-815, Copyright © 1985 by American Diabetes Association

ARTICLES

Plasma and skeletal muscle free amino acids in type I, insulin-treated diabetic subjects

L Borghi, R Lugari, A Montanari, P Dall'Argine, GF Elia, V Nicolotti, I Simoni, A Parmeggiani, A Novarini and A Gnudi

Insulin-dependent diabetes mellitus (IDDM) induces plasma amino acid (AA) abnormalities, including low alanine and high branched-chain (BCAA). While insulin treatment restores plasma AA pattern, proline, methionine, valine, isoleucine, and total BCAA remain elevated in skeletal muscle intracellular water. This suggests that the restoration of plasma AA concentrations is not a satisfactory index of recovered AA metabolism in IDDM.
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