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Diabetes, Vol 34, Issue 9 898-903, Copyright © 1985 by American Diabetes Association

ARTICLES

Structure, function, and immune properties of reassociated islet cells

J Shizuru, D Trager and RC Merrell

Rat islets were mechanically dissociated to single cells and allowed to form aggregates by rotation-mediated cell-cell interaction. The aggregates, or neoislets, demonstrated insulin release in response to 20 mM glucose and 10 mM theophylline that was comparable to that of intact islets cultured for a similar time. However, basal insulin release was considerably greater than that from freshly isolated islets. The microscopic structure of the neoislets revealed sorting into a B-cell domain at the surface with A-cells interior to the aggregate. The neoislets generated no mitogenic response in allogeneic lymph node lymphocytes. Reassociation of single islet cells provides stable, functional endocrine units with substantial reduction of immunogenicity.
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Copyright © 1985 by the American Diabetes Association.