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Diabetes, Vol 35, Issue 10 1090-1095, Copyright © 1986 by American Diabetes Association

ARTICLES

Immunohistochemical colocalization of GABA and insulin in beta-cells of rat islet

DJ Garry, RL Sorenson, RP Elde, BE Maley and A Madsen

gamma-Aminobutyric acid (GABA) is found in high concentrations in the pancreatic islet. In addition, enzymes regulating the level of GABA (L-glutamate decarboxylase and GABA-alpha-ketoglutarate transaminase) have been immunohistochemically localized in the medullary cells of the islet. In this study, an immunofluorescence and elution/restaining protocol is used to determine the distribution of GABA and either insulin, glucagon, or somatostatin in a tissue section. GABA was not detected within the islet alpha- or delta-cells but was determined to be localized within the insulin-containing beta-cells.
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Copyright © 1986 by the American Diabetes Association.