Diabetes, Vol 35, Issue 10 1158-1162, Copyright © 1986 by American Diabetes Association
Myocardial cell dysfunction in diabetes mellitus. A review of clinical and experimental studies
O Gotzsche
Evidence for an abnormal myocardial cell function in diabetes mellitus,
influenced by acute metabolic changes, has appeared within recent years.
Few but interesting clinical studies focus on this aspect of diabetic
cardiopathy, and experimental studies have delivered possible explanations
at the cellular level. These are concerned with the intracellular calcium
homeostasis and transsarcolemmal receptor signaling. Because these changes
are reversible by short-term insulin treatment, a new aspect for the study
of diabetic heart disease has appeared.