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Diabetes, Vol 35, Issue 10 1178-1180, Copyright © 1986 by American Diabetes Association

ARTICLES

Novel gene activated in rat insulinomas

S Takasawa, H Yamamoto, K Terazono and H Okamoto

Insulinomas can be induced in experimental animals by the combined administration of diabetogenic agents with polyadenosine diphosphate (polyADP)-ribose synthetase inhibitors. A complementary DNA (cDNA) library that was constructed from streptozocin-nicotinamide-induced rat insulinomas has been found to contain a novel gene encoding a basic protein of 145 amino acids. The gene was expressed in alloxan-nicotinamide-induced insulinomas as well as in streptozocin-nicotinamide-induced insulinomas but not in normal pancreatic islets or in regenerating islets. This indicates that the activation of the gene designated rig, i.e., rat insulinoma gene, may be a general feature of pancreatic beta-cell transformation.
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 Proc. Natl. Acad. Sci. USAHome page
P. Tranque, M. C.-Y. Hu, G. M. Edelman, and V. P. Mauro
rRNA complementarity within mRNAs: A possible basis for mRNA-ribosome interactions and translational control
PNAS, October 13, 1998; 95(21): 12238 - 12243.
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Copyright © 1986 by the American Diabetes Association.