Diabetes, Vol 36, Issue 2 205-209, Copyright © 1987 by American Diabetes Association

ARTICLES

Declining incidence of persistent proteinuria in type I (insulin-dependent) diabetic patients in Denmark

A Kofoed-Enevoldsen, K Borch-Johnsen, S Kreiner, J Nerup and T Deckert

The decreasing relative mortality among type I (insulin-dependent) diabetic patients during the last 50 years might be related to the incidence of clinical diabetic nephropathy. We therefore followed 2890 type I diabetic patients (1607 males and 1283 females) diagnosed between 1933 and 1972 and before the age of 31, from admission to death, emigration, or January 1, 1984. All patients had been admitted to the Steno Memorial Hospital. Information on development of proteinuria was obtained in 2658 patients (92%). Five hundred twenty-five patients developed proteinuria due to diabetes and 49 developed nondiabetic proteinuria. When comparing patients diagnosed between 1933 and 1942 with those diagnosed between 1953 and 1962, the incidence of proteinuria decreased by 30% (P less than .03). This might explain the decrease of relative mortality in type I diabetic patients. The incidence decreased with increasing age at onset but was always highest in males. Insulin dose (U/kg) and diabetes duration at admission did not influence the incidence of proteinuria. The incidence peaked after 15-17 yr of diabetes duration independent of sex, age at diagnosis, or calendar year of diagnosis. However, the majority of patients did not develop proteinuria during 40 yr of diabetes. This suggests individual renal susceptibility to the deleterious effect of hyperglycemia.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. D Deshpande, M. Harris-Hayes, and M. Schootman Epidemiology of Diabetes and Diabetes-Related Complications Physical Therapy, November 1, 2008; 88(11): 1254 - 1264. [Abstract] [Full Text] [PDF]

				G. Pambianco, T. Costacou, D. Ellis, D. J. Becker, R. Klein, and T. J. Orchard The 30-year natural history of type 1 diabetes complications: the pittsburgh epidemiology of diabetes complications study experience. Diabetes, May 1, 2006; 55(5): 1463 - 1469. [Abstract] [Full Text] [PDF]

				M. Svensson, L. Nystrom, S. Schon, G. Dahlquist, and on behalf of the Swedish Childhood Diabetes Study Age at Onset of Childhood-Onset Type 1 Diabetes and the Development of End-Stage Renal Disease: A nationwide population-based study. Diabetes Care, March 1, 2006; 29(3): 538 - 542. [Abstract] [Full Text] [PDF]

				M. E. Molitch, D. Rupp, and M. Carnethon Higher Levels of HDL Cholesterol Are Associated With a Decreased Likelihood of Albuminuria in Patients With Long-Standing Type 1 Diabetes Diabetes Care, January 1, 2006; 29(1): 78 - 82. [Abstract] [Full Text] [PDF]

				P. Finne, A. Reunanen, S. Stenman, P.-H. Groop, and C. Gronhagen-Riska Incidence of End-stage Renal Disease in Patients With Type 1 Diabetes JAMA, October 12, 2005; 294(14): 1782 - 1787. [Abstract] [Full Text] [PDF]

				M. Svensson, J. W. Eriksson, and G. Dahlquist Early Glycemic Control, Age at Onset, and Development of Microvascular Complications in Childhood-Onset Type 1 Diabetes: A population-based study in northern Sweden Diabetes Care, April 1, 2004; 27(4): 955 - 962. [Abstract] [Full Text] [PDF]

				M. Svensson, G. Sundkvist, H. J. Arnqvist, E. Bjork, G. Blohme, J. Bolinder, M. Henricsson, L. Nystrom, O. Torffvit, I. Waernbaum, et al. Signs of Nephropathy May Occur Early in Young Adults With Diabetes Despite Modern Diabetes Management: Results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS) Diabetes Care, October 1, 2003; 26(10): 2903 - 2909. [Abstract] [Full Text] [PDF]

				C. S. Arun, J. Stoddart, P. Mackin, J. M. MacLeod, J. P. New, and S. M. Marshall Significance of Microalbuminuria in Long-Duration Type 1 Diabetes Diabetes Care, July 1, 2003; 26(7): 2144 - 2149. [Abstract] [Full Text] [PDF]

				P. Hovind, L. Tarnow, K. Rossing, P. Rossing, S. Eising, N. Larsen, C. Binder, and H.-H. Parving Decreasing Incidence of Severe Diabetic Microangiopathy in Type 1 Diabetes Diabetes Care, April 1, 2003; 26(4): 1258 - 1264. [Abstract] [Full Text] [PDF]

				L. Poulsen Review: Early renal involvement in Type 1 diabetes mellitus -- Part 2: ACE inhibitor intervention in Type 1 diabetes with low grade microalbuminuria Journal of Renin-Angiotensin-Aldosterone System, March 1, 2003; 4(1): 17 - 26. [Abstract] [PDF]

				L. Poulsen Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes Journal of Renin-Angiotensin-Aldosterone System, December 1, 2002; 3(4): 222 - 242. [Abstract] [PDF]

				M. Mauer and K. Drummond The Early Natural History of Nephropathy in Type 1 Diabetes: I. Study Design and Baseline Characteristics of the Study Participants Diabetes, May 1, 2002; 51(5): 1572 - 1579. [Abstract] [Full Text] [PDF]

				L. J. Scott, J. H. Warram, L. S. Hanna, L. M. B. Laffel, L. Ryan, and A. S. Krolewski A Nonlinear Effect of Hyperglycemia and Current Cigarette Smoking Are Major Determinants of the Onset of Microalbuminuria in Type 1 Diabetes Diabetes, December 1, 2001; 50(12): 2842 - 2849. [Abstract] [Full Text] [PDF]

				A. V. Möllsten, G. G. Dahlquist, E.-L. Stattin, and S. Rudberg Higher Intakes of Fish Protein Are Related to a Lower Risk of Microalbuminuria in Young Swedish Type 1 Diabetic Patients Diabetes Care, May 1, 2001; 24(5): 805 - 810. [Abstract] [Full Text]

				V. O. Shah, R. I. Dorin, Y. Sun, M. Braun, and P. G. Zager Aldose Reductase Gene Expression Is Increased in Diabetic Nephropathy J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2294 - 2298. [Abstract] [Full Text] [PDF]

				M. Bojestig, H. J. Arnqvist, G. Hermansson, B. E. Karlberg, and J. Ludvigsson Declining Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus N. Engl. J. Med., January 6, 1994; 330(1): 15 - 18. [Abstract] [Full Text]