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Diabetes, Vol 36, Issue 3 284-287, Copyright © 1987 by American Diabetes Association

ARTICLES

Failure of genetically selected miniature swine to model NIDDM

MS Hand, RS Surwit, J Rodin, P Van Order and MN Feinglos

Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic diet; and 4 mo of excess diabetogenic diet for obesification. Results of oral glucose tolerance and intravenous insulin tolerance tests conducted at the end of each regimen were compared. Hyperglycemia was not observed in any animals after any manipulation. Insulin sensitivity was also not influenced by diet. We conclude that F7 low-K miniature swine from this colony fail to model human non-insulin-dependent diabetes.
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Copyright © 1987 by the American Diabetes Association.