Diabetes, Vol 36, Issue 4 454-458, Copyright © 1987 by American Diabetes Association

ARTICLES

Persistent impairment of insulin secretory response to glucose in adult rats after limited period of protein-calorie malnutrition early in life

I Swenne, CJ Crace and RD Milner

The effect of a limited period of protein-calorie malnutrition in young rats on glucose tolerance, insulin secretory response to glucose, and tissue composition in the adult was studied. Three-week-old rats were weaned onto semisynthetic diets containing either 5% protein (low protein; LP) or 15% protein (control; C) and maintained for 3 wk on their respective diets. At 6 wk of age all rats were returned to a commercial rat chow diet (18% protein). Glucose tolerance, insulin secretory response to glucose, and the protein/DNA ratio in liver, skeletal muscle, heart, kidney, small intestine, and lung were investigated at 3, 6, and 12 wk of age. Rats receiving LP diet failed to gain weight, but growth resumed immediately when they were transferred to commercial rat chow. They did not, however, catch up with C rats. Glucose tolerance and insulin secretory response to glucose remained similar between 3 and 12 wk in C rats. In 6-wk-old LP rats, glucose tolerance was impaired, and the insulin secretory response to glucose was absent. At 12 wk of age the glucose tolerance of the LP rats had normalized, but the insulin secretory response was still blunted. In 6-wk-old LP rats there was an inhibition of the age-dependent increase in cell size, shown by lowered protein/DNA ratios in all tissues studied. This decrease in cell size persisted at 12 wk in liver, skeletal muscle, heart, and lung. We conclude that protein-calorie malnutrition early in life persistently impairs the insulin secretion. The persistently lowered protein/DNA ratios in many tissues may be related to this lowered capacity for insulin secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Nilsson, P. Poulsen, M. Sjogren, C. Ling, M. Ridderstrale, L. Groop, and A. Vaag Regulation of skeletal muscle PPAR{delta} mRNA expression in twins J. Physiol., November 1, 2007; 584(3): 1011 - 1017. [Abstract] [Full Text] [PDF]

				K. R. Poore, J. K. Cleal, J. P. Newman, J. P. Boullin, D. E. Noakes, M. A. Hanson, and L. R. Green Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep Am J Physiol Endocrinol Metab, January 1, 2007; 292(1): E32 - E39. [Abstract] [Full Text] [PDF]

				F. Ferreira, H. C. L. Barbosa, L. F. Stoppiglia, V. Delghingaro-Augusto, E. A. Pereira, A. C. Boschero, and E. M. Carneiro Decreased Insulin Secretion in Islets from Rats Fed a Low Protein Diet Is Associated with a Reduced PKA{alpha} Expression J. Nutr., January 1, 2004; 134(1): 63 - 67. [Abstract] [Full Text] [PDF]

				K. Holemans, L. Aerts, and F. A. Van Assche Fetal Growth Restriction and Consequences for the Offspring in Animal Models Reproductive Sciences, October 1, 2003; 10(7): 392 - 399. [Abstract] [PDF]

				R. Crescenzo, S. Samec, V. Antic, F. Rohner-Jeanrenaud, J. Seydoux, J.-P. Montani, and A. G. Dulloo A Role for Suppressed Thermogenesis Favoring Catch-Up Fat in the Pathophysiology of Catch-Up Growth Diabetes, May 1, 2003; 52(5): 1090 - 1097. [Abstract] [Full Text] [PDF]

				F. Ferreira, E. Filiputti, V. C. Arantes, L. F. Stoppiglia, E. P. Araujo, V. Delghingaro-Augusto, M. Q. Latorraca, M. H. Toyama, A. C. Boschero, and E. M. Carneiro Decreased Cholinergic Stimulation of Insulin Secretion by Islets from Rats Fed a Low Protein Diet Is Associated with Reduced Protein Kinase C{alpha} Expression J. Nutr., March 1, 2003; 133(3): 695 - 699. [Abstract] [Full Text] [PDF]

				C. E Bertram and M. A Hanson Animal models and programming of the metabolic syndrome: Type 2 diabetes Br. Med. Bull., November 1, 2001; 60(1): 103 - 121. [Abstract] [Full Text] [PDF]

				S. E Ozanne Metabolic programming in animals: Type 2 diabetes Br. Med. Bull., November 1, 2001; 60(1): 143 - 152. [Abstract] [Full Text] [PDF]

				B. S. Cha, C. W. Ahn, Y. D. Song, S. K. Lim, K. R. Kim, K. B. Huh, and H. C. Lee Chronic Alcohol Intake Differently Influences Glucose Metabolism According to Nutritional Status J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3646 - 3652. [Abstract] [Full Text]

				C. Alvarez, D. Bailbe, F. Picarel-Blanchot, E. Bertin, A.-M. Pascual-Leone, and B. Portha Effect of early dietary restriction on insulin action and secretion in the GK rat, a spontaneous model of NIDDM Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1097 - E1103. [Abstract] [Full Text] [PDF]

				M. D. McArthur, D. You, K. Klapstein, and D. T. Finegood Glucose effectiveness is the major determinant of intravenous glucose tolerance in the rat Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E739 - E746. [Abstract] [Full Text] [PDF]

				R. A Waterland and C. Garza Potential mechanisms of metabolic imprinting that lead to chronic disease Am. J. Clinical Nutrition, February 1, 1999; 69(2): 179 - 197. [Abstract] [Full Text] [PDF]

				M. J. Holness and M. C. Sugden Antecedent protein restriction exacerbates development of impaired insulin action after high-fat feeding Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E85 - E93. [Abstract] [Full Text] [PDF]

				T. Leon-Quinto, C. Magnan, and B. Portha Altered Activity of the Autonomous Nervous System as a Determinant of the Impaired {beta}-Cell Secretory Response after Protein-Energy Restriction in the Rat Endocrinology, August 1, 1998; 139(8): 3382 - 3389. [Abstract] [Full Text] [PDF]

				A A. Sayer, C Cooper, and D J P Barker Is lifespan determined in utero? Arch. Dis. Child. Fetal Neonatal Ed., November 1, 1997; 77(3): 162F - 164. [Full Text]

				G. C. Curhan, W. C. Willett, E. B. Rimm, D. Spiegelman, A. L. Ascherio, and M. J. Stampfer Birth Weight and Adult Hypertension, Diabetes Mellitus, and Obesity in US Men Circulation, December 15, 1996; 94(12): 3246 - 3250. [Abstract] [Full Text]

				D R McCance, D J Pettitt, R L Hanson, L T H Jacobsson, W C Knowler, and P H Bennett Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ, April 9, 1994; 308(6934): 942 - 945. [Abstract] [Full Text]