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Diabetes, Vol 36, Issue 4 546-549, Copyright © 1987 by American Diabetes Association

ARTICLES

Polymorphic human glucose transporter gene (GLUT) is on chromosome 1p31.3----p35

TB Shows, RL Eddy, MG Byers, Y Fukushima, CR Dehaven, JC Murray and GI Bell

The glucose transporter is a membrane glycoprotein that is involved in the uptake of glucose by most, if not all, animal cells. A cloned cDNA that encodes the human protein was used to map the gene to a specific chromosomal region and to identify a DNA polymorphism. The human gene (designated GLUT) was assigned to chromosome 1p31.3----p35 by hybridization of the probe to DNA from a panel of human-mouse somatic cell hybrids containing different human chromosomes and by in situ hybridization to isolated metaphase chromosomes. The most likely location of GLUT is in 1p33. A common two-allele restriction-fragment-length polymorphism was identified with Xba I.
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Copyright © 1987 by the American Diabetes Association.