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Diabetes, Vol 36, Issue 6 779-781, Copyright © 1987 by American Diabetes Association

ARTICLES

Regulation of insulin-receptor mRNA levels by glucocorticoids

AR McDonald, BA Maddux, Y Okabayashi, KY Wong, DM Hawley, CD Logsdon and ID Goldfine

We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1987 by the American Diabetes Association.