Diabetes, Vol 36, Issue 8 978-981, Copyright © 1987 by American Diabetes Association

ARTICLES

Endothelium-dependent relaxation in aorta of BB rat

S Meraji, L Jayakody, MP Senaratne, AB Thomson and T Kappagoda

The study was undertaken to determine whether the phenomenon of endothelium-dependent relaxation was impaired in the spontaneously diabetic BB Wistar rat. Endothelium-dependent relaxation in the aorta of overtly diabetic animals was compared with that in nondiabetic BB rats. The relaxative responses were elicited in vitro to acetylcholine (-8.0 to -5.5 log M) and histamine (-7.0 to -3.0 log M) after precontraction with norepinephrine (-6.0 log M). The maximum relaxations produced by both acetylcholine and histamine expressed as percentages of the contractions to norepinephrine were significantly lower in diabetic than in nondiabetic rats. Scanning electron microscopy revealed that in diabetic BB rats there was consistent evidence of swollen cells, raised nuclei, and sloughing of nuclei in endothelial cells of the aorta. In nondiabetic animals these features were not evident. These findings suggest the presence of a functional and morphological defect in endothelial cells in the aorta of the BB rat.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. H. McNulty, M. A. Tulli, B. J. Robertson, V. Lendel, L. A. Harach, S. Scott, and J. P. Boehmer Effect of simulated postprandial hyperglycemia on coronary blood flow in cardiac transplant recipients Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H103 - H108. [Abstract] [Full Text] [PDF]

				C. J. Zuurbier, C. Demirci, A. Koeman, H. Vink, and C. Ince Short-term hyperglycemia increases endothelial glycocalyx permeability and acutely decreases lineal density of capillaries with flowing red blood cells J Appl Physiol, October 1, 2005; 99(4): 1471 - 1476. [Abstract] [Full Text] [PDF]

				A. Ceriello and E. Motz Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 816 - 823. [Abstract] [Full Text]

				J. A. Beckman, A. B. Goldfine, M. B. Gordon, L. A. Garrett, J. F. Keaney Jr., and M. A. Creager Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2392 - H2398. [Abstract] [Full Text] [PDF]

				M. A. Creager, T. F. Luscher, F. Cosentino, and J. A. Beckman Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I Circulation, September 23, 2003; 108(12): 1527 - 1532. [Full Text] [PDF]

				A. Ceriello New Insights on Oxidative Stress and Diabetic Complications May Lead to a "Causal" Antioxidant Therapy Diabetes Care, May 1, 2003; 26(5): 1589 - 1596. [Abstract] [Full Text] [PDF]

				Y. K. Kim, M.-S. Lee, S. M. Son, I. J. Kim, W. S. Lee, B. Y. Rhim, K. W. Hong, and C. D. Kim Vascular NADH Oxidase Is Involved in Impaired Endothelium-Dependent Vasodilation in OLETF Rats, a Model of Type 2 Diabetes Diabetes, February 1, 2002; 51(2): 522 - 527. [Abstract] [Full Text] [PDF]

				J. A. Beckman, A. B. Goldfine, M. B. Gordon, and M. A. Creager Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans Circulation, March 27, 2001; 103(12): 1618 - 1623. [Abstract] [Full Text] [PDF]

				L. Michea, V. Irribarra, I. A. Goecke, and E. T. Marusic Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H851 - H858. [Abstract] [Full Text] [PDF]

				M. J. Mullen, D. Wright, A. E. Donald, S. Thorne, H. Thomson, and J. E. Deanfield Atorvastatin but not L-arginine improves endothelial function in type I diabetes mellitus: a double-blind study J. Am. Coll. Cardiol., August 1, 2000; 36(2): 410 - 416. [Abstract] [Full Text] [PDF]

				F. M. Ho, S. H. Liu, C. S. Liau, P. J. Huang, and S. Y. Lin-Shiau High Glucose-Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH2-Terminal Kinase and Caspase-3 Circulation, June 6, 2000; 101(22): 2618 - 2624. [Abstract] [Full Text] [PDF]

				S. Kilo, M. Berghoff, M. Hilz, and R. Freeman Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy Neurology, March 28, 2000; 54(6): 1246 - 1252. [Abstract] [Full Text] [PDF]

				D. D. Lund, F. M. Faraci, F. J. Miller Jr, and D. D. Heistad Gene Transfer of Endothelial Nitric Oxide Synthase Improves Relaxation of Carotid Arteries From Diabetic Rabbits Circulation, March 7, 2000; 101(9): 1027 - 1033. [Abstract] [Full Text] [PDF]

				A. Abaci, S. Kahraman, N. K. Eryol, H. Arinc, and A. Ergin Effect of Diabetes Mellitus on Formation of Coronary Collateral Vessels Circulation, May 4, 1999; 99(17): 2239 - 2242. [Abstract] [Full Text] [PDF]

				R. V. Hogikyan, A. T. Galecki, B. Pitt, J. B. Halter, D. A. Greene, and M. A. Supiano Specific Impairment of Endothelium-Dependent Vasodilation in Subjects with Type 2 Diabetes Independent of Obesity J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 1946 - 1952. [Abstract] [Full Text]

				S. B. Williams, A. B. Goldfine, F. K. Timimi, H. H. Ting, M.-A. Roddy, D. C. Simonson, and M. A. Creager Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo Circulation, May 5, 1998; 97(17): 1695 - 1701. [Abstract] [Full Text] [PDF]

				G. M. Pieper Review of Alterations in Endothelial Nitric Oxide Production in Diabetes : Protective Role of Arginine on Endothelial Dysfunction Hypertension, May 1, 1998; 31(5): 1047 - 1060. [Full Text] [PDF]

				S. Makimattila, A. Virkamaki, P.-H. Groop, J. Cockcroft, T. Utriainen, J. Fagerudd, and H. Yki-Jarvinen Chronic Hyperglycemia Impairs Endothelial Function and Insulin Sensitivity Via Different Mechanisms in Insulin-Dependent Diabetes Mellitus Circulation, September 15, 1996; 94(6): 1276 - 1282. [Abstract] [Full Text]

				P. J. Nahser Jr, R. E. Brown, H. Oskarsson, M. D. Winniford, and J. D. Rossen Maximal Coronary Flow Reserve and Metabolic Coronary Vasodilation in Patients With Diabetes Mellitus Circulation, February 1, 1995; 91(3): 635 - 640. [Abstract] [Full Text]

				J. A. Beckman, A. B. Goldfine, M. B. Gordon, L. A. Garrett, and M. A. Creager Inhibition of Protein Kinase C{beta} Prevents Impaired Endothelium-Dependent Vasodilation Caused by Hyperglycemia in Humans Circ. Res., January 11, 2002; 90(1): 107 - 111. [Abstract] [Full Text] [PDF]