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Diabetes, Vol 37, Issue 1 130-132, Copyright © 1988 by American Diabetes Association

ARTICLES

Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment

B Kuglin, FA Gries and H Kolb
Diabetes Research Institute, University of Dusseldorf, Federal Republic of Germany.

IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference. Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in the immune process of IDDM.
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