Diabetes, Vol 37, Issue 2 154-159, Copyright © 1988 by American Diabetes Association

ARTICLES

Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction

JK Zawadzki, RR Wolfe, DM Mott, S Lillioja, BV Howard and C Bogardus
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix.

To determine the contribution of the rate of glucose recycling via the Cori cycle (glucose----3-carbon compounds----glucose) to the higher rate of endogenous glucose production (EGPR) in subjects with non-insulin-dependent diabetes mellitus (NIDDM), we studied eight obese, weight-stabilized diabetic Pima Indians before [93.1 +/- 5.4 kg, 38 +/- 2% body fat, fasting plasma glucose (FPG) 254 +/- 11 mg/dl] and after (87.7 +/- 4.7 kg, 36 +/- 2% body fat, FPG 153 +/- 17 mg/dl) a 5-wk weight-loss diet and eight obese Indians (95.0 +/- 4.2 kg, 36 +/- 2% body fat, FPG 97 +/- 1 mg/dl) with normal glucose tolerance. EGPR and glucose recycling rate were measured during a 4-h primed continuous tracer infusion of [1-13C]glucose, and the rate of reincorporation of 1-13C of glucose into C2-6 positions in glucose was quantified by gas chromatography mass spectrometry. Substrate utilization rates were measured by simultaneous indirect calorimetry. EGPR (corrected for measured rate of recycling) decreased in the diabetic subjects from 3.80 to 2.74 mg.min-1.kg-1 fat-free mass (FFM) (P less than .01) after weight loss, approaching the rate observed in nondiabetic subjects (2.09 mg.min-1.kg-1 FFM).(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. Bouzakri, R. Austin, A. Rune, M. E. Lassman, P. M. Garcia-Roves, J. P. Berger, A. Krook, A. V. Chibalin, B. B. Zhang, and J. R. Zierath Malonyl CoenzymeA Decarboxylase Regulates Lipid and Glucose Metabolism in Human Skeletal Muscle Diabetes, June 1, 2008; 57(6): 1508 - 1516. [Abstract] [Full Text] [PDF]

				V. Qvisth, E. Hagstrom-Toft, E. Moberg, S. Sjoberg, and J. Bolinder Lactate release from adipose tissue and skeletal muscle in vivo: defective insulin regulation in insulin-resistant obese women Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E709 - E714. [Abstract] [Full Text] [PDF]

				P. D. van Poelje, S. C. Potter, V. C. Chandramouli, B. R. Landau, Q. Dang, and M. D. Erion Inhibition of Fructose 1,6-Bisphosphatase Reduces Excessive Endogenous Glucose Production and Attenuates Hyperglycemia in Zucker Diabetic Fatty Rats Diabetes, June 1, 2006; 55(6): 1747 - 1754. [Abstract] [Full Text] [PDF]

				P. Vuguin, E. Raab, B. Liu, N. Barzilai, and R. Simmons Hepatic Insulin Resistance Precedes the Development of Diabetes in a Model of Intrauterine Growth Retardation Diabetes, October 1, 2004; 53(10): 2617 - 2622. [Abstract] [Full Text] [PDF]

				I. E. Peterside, M. A. Selak, and R. A. Simmons Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1258 - E1266. [Abstract] [Full Text] [PDF]

				J.-M. Schwarz, P. Linfoot, D. Dare, and K. Aghajanian Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets Am. J. Clinical Nutrition, January 1, 2003; 77(1): 43 - 50. [Abstract] [Full Text] [PDF]

				G. Boden, X. Chen, and T. P. Stein Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E23 - E30. [Abstract] [Full Text] [PDF]

				A. Balasubramanyam, S. McKay, P. Nadkarni, A. S. Rajan, A. Garza, V. Pavlik, J. A. Herd, F. Jahoor, and P. J. Reeds Ethnicity affects the postprandial regulation of glycogenolysis Am J Physiol Endocrinol Metab, November 1, 1999; 277(5): E905 - E914. [Abstract] [Full Text] [PDF]