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Diabetes, Vol 37, Issue 2 209-212, Copyright © 1988 by American Diabetes Association

ARTICLES

Interferon-gamma induces class II MHC antigens on RINm5F cells

AM Varey, PM Lydyard, BM Dean, PH Van der Meide, JD Baird and A Cooke
Department of Immunology, Middlesex Hospital Medical School, London, England.

The ability of recombinant interferon-gamma (rIFN-gamma) to induce major histocompatibility complex (MHC) antigen expression in the rat insulinoma cell line RINm5F was investigated. The cells were stained with monoclonal antibodies specific for rat class I and class II MHC antigens. RINm5F cells endogenously expressed class I antigens; this was enhanced by rIFN-gamma. Class II antigens could not be detected on RINm5F cells, but both I-A and I-E were induced by rIFN-gamma.
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Copyright © 1988 by the American Diabetes Association.