Diabetes, Vol 37, Issue 5 622-628, Copyright © 1988 by American Diabetes Association

ARTICLES

Congenital susceptibility to NIDDM. Role of intrauterine environment

DJ Pettitt, KA Aleck, HR Baird, MJ Carraher, PH Bennett and WC Knowler
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona 85014.

Non-insulin-dependent diabetes mellitus (NIDDM) during pregnancy in Pima Indian women results in offspring who have a higher prevalence of NIDDM (45%) at age 20-24 yr than in offspring of nondiabetic women (1.4%) or offspring of prediabetic women (8.6%), i.e., women who developed diabetes only after the pregnancy. These differences persist after taking into account paternal diabetes, age at onset of diabetes in the parents, and the offspring's weight relative to height. The findings suggest that the intrauterine environment is an important determinant of the development of diabetes and that its effect is in addition to effects of genetic factors.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. R. Coustan A 40-Year-Old Woman With Diabetes Contemplating Pregnancy After Gastric Bypass Surgery JAMA, June 4, 2008; 299(21): 2550 - 2557. [Abstract] [Full Text] [PDF]

				D. A. Ingram, I. Z. Lien, L. E. Mead, M. Estes, D. N. Prater, E. Derr-Yellin, L. A. DiMeglio, and L. S. Haneline In Vitro Hyperglycemia or a Diabetic Intrauterine Environment Reduces Neonatal Endothelial Colony-Forming Cell Numbers and Function Diabetes, March 1, 2008; 57(3): 724 - 731. [Abstract] [Full Text] [PDF]

				P. W. Franks, R. L. Hanson, W. C. Knowler, C. Moffett, G. Enos, A. M. Infante, J. Krakoff, and H. C. Looker Childhood Predictors of Young-Onset Type 2 Diabetes Diabetes, December 1, 2007; 56(12): 2964 - 2972. [Abstract] [Full Text] [PDF]

				C. S. Yajnik, K. Godbole, S. R. Otiv, and H. G. Lubree Fetal Programming of Type 2 Diabetes: Is sex important? Diabetes Care, October 1, 2007; 30(10): 2754 - 2755. [Full Text] [PDF]

				T. A. Hillier, K. L. Pedula, M. M. Schmidt, J. A. Mullen, M.-A. Charles, and D. J. Pettitt Childhood Obesity and Metabolic Imprinting: The ongoing effects of maternal hyperglycemia Diabetes Care, September 1, 2007; 30(9): 2287 - 2292. [Abstract] [Full Text] [PDF]

				J. Han, J. Xu, Y. S. Long, P. N. Epstein, and Y. Q. Liu Rat maternal diabetes impairs pancreatic beta-cell function in the offspring Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E228 - E236. [Abstract] [Full Text] [PDF]

				A. Ferrara Increasing Prevalence of Gestational Diabetes Mellitus: A public health perspective Diabetes Care, July 1, 2007; 30(Supplement_2): S141 - S146. [Full Text] [PDF]

				L. Rode, H. K. Hegaard, H. Kjaergaard, L. F. Moller, A. Tabor, and B. Ottesen Association Between Maternal Weight Gain and Birth Weight Obstet. Gynecol., June 1, 2007; 109(6): 1309 - 1315. [Abstract] [Full Text] [PDF]

				I. Arfa, A. Abid, D. Malouche, N. Ben Alaya, T. Roland Azegue, I. Mannai, M. Majdi Zorgati, M. Chiheb Ben Rayana, S. Ben Ammar, S. Blousa-Chabchoub, et al. Familial aggregation and excess maternal transmission of type 2 diabetes in Tunisia Postgrad. Med. J., May 1, 2007; 83(979): 348 - 351. [Abstract] [Full Text] [PDF]

				C. Thomas, E. Hypponen, and C. Power Prenatal Exposures and Glucose Metabolism in Adulthood: Are effects mediated through birth weight and adiposity? Diabetes Care, April 1, 2007; 30(4): 918 - 924. [Abstract] [Full Text] [PDF]

				D I. Phillips External influences on the fetus and their long-term consequences Lupus, November 1, 2006; 15(11): 794 - 800. [Abstract] [PDF]

				L.-S. Fetita, E. Sobngwi, P. Serradas, F. Calvo, and J.-F. Gautier Consequences of Fetal Exposure to Maternal Diabetes in Offspring J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 3718 - 3724. [Abstract] [Full Text] [PDF]

				J. A. Westgate, R. S. Lindsay, J. Beattie, N. S. Pattison, G. Gamble, L. F.J. Mildenhall, B. H. Breier, and F. D. Johnstone Hyperinsulinemia in Cord Blood in Mothers With Type 2 Diabetes and Gestational Diabetes Mellitus in New Zealand. Diabetes Care, June 1, 2006; 29(6): 1345 - 1350. [Abstract] [Full Text] [PDF]

				P. W. Franks, H. C. Looker, S. Kobes, L. Touger, P. A. Tataranni, R. L. Hanson, and W. C. Knowler Gestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring Diabetes, February 1, 2006; 55(2): 460 - 465. [Abstract] [Full Text] [PDF]

				G. V. Krishnaveni, J. C. Hill, S. D. Leary, S. R. Veena, J. Saperia, A. Saroja, S. C. Karat, and C. H.D. Fall Anthropometry, Glucose Tolerance, and Insulin Concentrations in Indian Children: Relationships to maternal glucose and insulin concentrations during pregnancy Diabetes Care, December 1, 2005; 28(12): 2919 - 2925. [Abstract] [Full Text] [PDF]

				J. A. Armitage, P. D. Taylor, and L. Poston Experimental models of developmental programming: consequences of exposure to an energy rich diet during development J. Physiol., May 15, 2005; 565(1): 3 - 8. [Abstract] [Full Text] [PDF]

				L. Touger, H. C. Looker, J. Krakoff, R. S. Lindsay, V. Cook, and W. C. Knowler Early Growth in Offspring of Diabetic Mothers Diabetes Care, March 1, 2005; 28(3): 585 - 589. [Abstract] [Full Text] [PDF]

				J. B. Meigs, J. Dupuis, A. G. Herbert, C. Liu, P. W. F. Wilson, and L. A. Cupples The Insulin Gene Variable Number Tandem Repeat and Risk of Type 2 Diabetes in a Population-Based Sample of Families and Unrelated Men and Women J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 1137 - 1143. [Abstract] [Full Text] [PDF]

				D. A. Lawlor, J. M. Najman, J. Sterne, G. M. Williams, S. Ebrahim, and G. D. Smith Associations of Parental, Birth, and Early Life Characteristics With Systolic Blood Pressure at 5 Years of Age: Findings From the Mater-University Study of Pregnancy and Its Outcomes Circulation, October 19, 2004; 110(16): 2417 - 2423. [Abstract] [Full Text] [PDF]

				L. Jovanovic Never Say Never in Medicine: Confessions of an old dog Diabetes Care, February 1, 2004; 27(2): 610 - 612. [Full Text] [PDF]

				R. Hardy, M. E. Wadsworth, C. Langenberg, and D. Kuh Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort Int. J. Epidemiol., February 1, 2004; 33(1): 121 - 129. [Abstract] [Full Text] [PDF]

				K. Holemans, L. Aerts, and F. A. Van Assche Fetal Growth Restriction and Consequences for the Offspring in Animal Models Reproductive Sciences, October 1, 2003; 10(7): 392 - 399. [Abstract] [PDF]

				C. S. Yajnik, C. V. Joglekar, A. N. Pandit, A. R. Bavdekar, S. A. Bapat, S. A. Bhave, S. D. Leary, and C. H.D. Fall Higher Offspring Birth Weight Predicts the Metabolic Syndrome in Mothers but Not Fathers 8 Years After Delivery: The Pune Children's Study Diabetes, August 1, 2003; 52(8): 2090 - 2096. [Abstract] [Full Text] [PDF]

				M. Thamotharan, R. A. McKnight, S. Thamotharan, D. J. Kao, and S. U. Devaskar Aberrant insulin-induced GLUT4 translocation predicts glucose intolerance in the offspring of a diabetic mother Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E901 - E914. [Abstract] [Full Text] [PDF]

				J.-N. Wei, F.-C. Sung, C.-Y. Li, C.-H. Chang, R.-S. Lin, C.-C. Lin, C.-C. Chiang, and L.-M. Chuang Low Birth Weight and High Birth Weight Infants Are Both at an Increased Risk to Have Type 2 Diabetes Among Schoolchildren in Taiwan Diabetes Care, February 1, 2003; 26(2): 343 - 348. [Abstract] [Full Text] [PDF]

				A. Stride, M. Shepherd, T. M. Frayling, M. P. Bulman, S. Ellard, and A. T. Hattersley Intrauterine Hyperglycemia Is Associated With an Earlier Diagnosis of Diabetes in HNF-1{alpha} Gene Mutation Carriers Diabetes Care, December 1, 2002; 25(12): 2287 - 2291. [Abstract] [Full Text] [PDF]

				K. J. Acton, N. Rios Burrows, K. Moore, L. Querec, L. S. Geiss, and M. M. Engelgau Trends in Diabetes Prevalence Among American Indian and Alaska Native Children, Adolescents, and Young Adults Am J Public Health, September 1, 2002; 92(9): 1485 - 1490. [Abstract] [Full Text] [PDF]

				J. Boloker, S. J. Gertz, and R. A. Simmons Gestational Diabetes Leads to the Development of Diabetes in Adulthood in the Rat Diabetes, May 1, 2002; 51(5): 1499 - 1506. [Abstract] [Full Text] [PDF]

				J. Weng, M. Ekelund, M. Lehto, H. Li, G. Ekberg, A. Frid, A. Aberg, L. C. Groop, and K. Berntorp Screening for MODY Mutations, GAD Antibodies, and Type 1 Diabetes- Associated HLA Genotypes in Women With Gestational Diabetes Mellitus Diabetes Care, January 1, 2002; 25(1): 68 - 71. [Abstract] [Full Text] [PDF]

				L. Jovanovic and D. J. Pettitt Gestational Diabetes Mellitus JAMA, November 28, 2001; 286(20): 2516 - 2518. [Full Text] [PDF]

				R. S Lindsay and P. H Bennett Type 2 diabetes, the thrifty phenotype - an overview Br. Med. Bull., November 1, 2001; 60(1): 21 - 32. [Full Text] [PDF]

				F. A Van Assche, K. Holemans, and L. Aerts Long-term consequences for offspring of diabetes during pregnancy Br. Med. Bull., November 1, 2001; 60(1): 173 - 182. [Abstract] [Full Text] [PDF]

				B. Thorand, A. D Liese, M.-H. Metzger, P. Reitmeir, A. Schneider, and H. Lowel Can inaccuracy of reported parental history of diabetes explain the maternal transmission hypothesis for diabetes? Int. J. Epidemiol., October 1, 2001; 30(5): 1084 - 1089. [Abstract] [Full Text] [PDF]

				J.-F. Gautier, C. Wilson, C. Weyer, D. Mott, W. C. Knowler, M. Cavaghan, K. S. Polonsky, C. Bogardus, and R. E. Pratley Low Acute Insulin Secretory Responses in Adult Offspring of People With Early Onset Type 2 Diabetes Diabetes, August 1, 2001; 50(8): 1828 - 1833. [Abstract] [Full Text] [PDF]

				H. Yamashita, J. Shao, T. Ishizuka, P. J. Klepcyk, P. Muhlenkamp, L. Qiao, N. Hoggard, and J. E. Friedman Leptin Administration Prevents Spontaneous Gestational Diabetes in Heterozygous Leprdb/+ Mice: Effects on Placental Leptin and Fetal Growth Endocrinology, July 1, 2001; 142(7): 2888 - 2897. [Abstract] [Full Text] [PDF]

				R T Erasmus, E B. Blanco, A B Okesina, J M. Arana, Z Gqweta, and T Matsha Importance of family history in type 2 black South African diabetic patients Postgrad. Med. J., May 1, 2001; 77(907): 323 - 325. [Abstract] [Full Text]

				N. Fischel-Ghodsian Mitochondrial DNA Mutations and Diabetes: Another Step toward Individualized Medicine Ann Intern Med, May 1, 2001; 134(9_Part_1): 777 - 779. [Full Text] [PDF]

				Z. Nachum, I. Ben-Shlomo, E. Weiner, and E. Shalev Twice daily versus four times daily insulin dose regimens for diabetes in pregnancy: randomised controlled trial BMJ, November 6, 1999; 319(7219): 1223 - 1227. [Abstract] [Full Text]

				Y. Momiyama, Y. Suzuki, F. Ohsuzu, Y. Atsumi, K. Matsuoka, and M. Kimura Maternally transmitted susceptibility to non-insulin-dependent diabetes mellitus and left ventricular hypertrophy J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1372 - 1378. [Abstract] [Full Text] [PDF]

				J. W. Rich-Edwards, G. A. Colditz, M. J. Stampfer, W. C. Willett, M. W. Gillman, C. H. Hennekens, F. E. Speizer, and J. E. Manson Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women Ann Intern Med, February 16, 1999; 130(4_Part_1): 278 - 284. [Abstract] [Full Text] [PDF]

				R. A Waterland and C. Garza Potential mechanisms of metabolic imprinting that lead to chronic disease Am. J. Clinical Nutrition, February 1, 1999; 69(2): 179 - 197. [Abstract] [Full Text] [PDF]

				V.V. Cook and J.S. Hurley Prevention of Type 2 Diabetes in Childhood Clinical Pediatrics, February 1, 1998; 37(2): 123 - 129. [Abstract] [PDF]

				J. d. A C Soares, A. Dornhorstt, and R. W Beard Should we screen for gestational diabetes? The case for screening for gestational diabetes BMJ, September 20, 1997; 315(7110): 737 - 739. [Full Text]

				B. S. Singh, T. C. Westfall, and S. U. Devaskar Maternal Diabetes-Induced Hyperglycemia and Acute Intracerebral Hyperinsulinism Suppress Fetal Brain Neuropeptide Y Concentrations Endocrinology, March 1, 1997; 138(3): 963 - 969. [Abstract] [Full Text] [PDF]

				R. S. Lindsay, R. M. Lindsay, C. R.W. Edwards, and J. R. Seckl Inhibition of 11ß-Hydroxysteroid Dehydrogenase in Pregnant Rats and the Programming of Blood Pressure in the Offspring Hypertension, June 1, 1996; 27(6): 1200 - 1204. [Abstract] [Full Text]

				D. A Leon, I. Koupilova, H. O Lithell, L. Berglund, R. Mohsen, D. Vagero, U.-B. Lithell, and P. M McKeigue Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men BMJ, February 17, 1996; 312(7028): 401 - 406. [Abstract] [Full Text]

				A. Dornhorst and J. C. Girling Management of Gestational Diabetes Mellitus N. Engl. J. Med., November 9, 1995; 333(19): 1281 - 1283. [Full Text]

				R. G. Moses and R. D. Griffiths Can a Diagnosis of Gestational Diabetes Be an Advantage to the Outcome of Pregnancy? Reproductive Sciences, May 1, 1995; 2(3): 523 - 525. [Abstract] [PDF]

				D R McCance, D J Pettitt, R L Hanson, L T H Jacobsson, W C Knowler, and P H Bennett Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ, April 9, 1994; 308(6934): 942 - 945. [Abstract] [Full Text]

				A. Ferrara, H. S. Kahn, C. P. Quesenberry, C. Riley, and M. M. Hedderson An Increase in the Incidence of Gestational Diabetes Mellitus: Northern California, 1991-2000 Obstet. Gynecol., January 1, 1991; 103(3): 526 - 533. [Abstract] [Full Text]