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Diabetes, Vol 37, Issue 8 1049-1052, Copyright © 1988 by American Diabetes Association

ARTICLES

Cyclosporin A suppresses insulin autoantibodies and heterologous insulin antibodies in type I diabetic children

L Castano, C Boitard and PF Bougneres
Institut National de la Sante et de la Recherche Medicale (U 188), Hopital St Vincent de Paul, Paris, France.

We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.
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Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1988 by the American Diabetes Association.