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Diabetes, Vol 37, Issue 8 1068-1070, Copyright © 1988 by American Diabetes Association

ARTICLES

Identification of nucleotide substitution in gene encoding [LeuA3]insulin in third Japanese family

T Awata, Y Iwamoto, A Matsuda and T Kuzuya
Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi-ken, Japan.

We previously described a new case of abnormal insulinemia in Japan. In one allele, nucleotide-sequence analysis revealed a substitution in the codon for the third position of insulin A chain (GTG----TTG), causing [LeuA3]insulin. This point mutation is the same as that found in insulin Wakayama. In this family, the mutant insulin allele cosegregated with an 850-base pair PvuII allele of the hypervariable region 5'-flanking the insulin gene.
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Copyright © 1988 by the American Diabetes Association.