Diabetes, Vol 38, Issue 12 1528-1533, Copyright © 1989 by American Diabetes Association

ARTICLES

Reduction of glycemic and lipid levels in db/db diabetic mice by psyllium plant fiber

K Watters and P Blaisdell
Division of Health and Personal Care, Procter and Gamble Corporation, Cincinnati, Ohio 45241.

The soluble plant fiber psyllium significantly reduced fasting glucose and total cholesterol levels in the C57BL/KsJ db/db diabetic mouse relative to placebo-fed mice. Insulin levels were significantly higher in psyllium-fed than placebo-fed animals, indicating this fiber may delay the progression of diabetes in the animal model. High-density lipoprotein cholesterol levels rose moderately in both psyllium- and placebo-fed animals during the study, whereas triglyceride levels remained unchanged in both groups. Psyllium's effect on glycemic, lipid, and hormone parameters was not explained by weight loss or reduced food intake; these were similar in psyllium- and placebo-fed animals during the study. Our results show that psyllium fiber can beneficially moderate glycemic and lipid parameters in the db/db diabetes model.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?