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Diabetes, Vol 38, Issue 12 1623-1629, Copyright © 1989 by American Diabetes Association

ARTICLES

Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats

HA Voorbij, PH Jeucken, PJ Kabel, M De Haan and HA Drexhage
Department of Pathology, Free University Hospital, Amsterdam, The Netherlands.

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease whose notorious pathologic feature is insulitis accompanied by destruction of beta-cells. In this morphological study, we examined the pancreatic events during the onset of diabetes in spontaneously diabetic BB/Organon rats. Dendritic cells were the first cells to accumulate around the islets, followed by lymphocytes. Scavenger macrophages and MHC class II-positive beta-cells were only seen late in the disease. These observations suggest a role for antigen-presenting dendritic cells in the onset of the beta-cell-specific autoimmune reaction and emphasize the necessity to distinguish between the several monocyte-macrophage subtypes in studies on the pathogenesis of IDDM.
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