Diabetes, Vol 38, Issue 12 1647-1651, Copyright © 1989 by American Diabetes Association

ARTICLES

Prevention of diabetes in NOD mice by injection of autoreactive T-lymphocytes

EP Reich, D Scaringe, J Yagi, RS Sherwin and CA Janeway
Section of Immunobiology, Howard Hughes Medical Institute, New Haven, Connecticut.

The nonobese diabetic (NOD) mouse develops a high incidence of autoimmune diabetes and is believed to be a good model for insulin-dependent diabetes mellitus (IDDM) in humans. We isolated T-lymphocyte lines from islets of newly diabetic NOD mice, some of which are autoreactive to NOD spleen cells. Because autoreactive T-lymphocytes have been implicated in immune suppression, we injected NOD mice with an autoreactive T-lymphocyte line. The injected mice had a marked decrease in incidence of IDDM compared with control mice. Moreover, their islets showed no insulitis at 1 yr of age. We conclude that autoreactive T-lymphocytes can prevent the development of IDDM in NOD mice. This result suggests that 1) islets contain both effector cells capable of damaging pancreatic beta-cells and cells able to regulate this autoimmune response, and 2) development of IDDM depends on the balance between these opposing forces.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Pastorale, M. Arata, A. Caminos, L. Bruno, J. Basabe, and H. Chemes Effect of Modified Diabetic Splenocytes on Mice Injected with Multiple Low-Dose Streptozotocin Experimental Biology and Medicine, April 1, 2002; 227(4): 282 - 289. [Abstract] [Full Text] [PDF]

				A. Y. Savinov, F. S. Wong, and A. V. Chervonsky IFN-{gamma} Affects Homing of Diabetogenic T Cells J. Immunol., December 1, 2001; 167(11): 6637 - 6643. [Abstract] [Full Text] [PDF]

				M. Arata, L. Bruno, C. Pastorale, F. Pagliero, and J. C. Basabe Effect of Modified Diabetic Splenocytes on Mice Injected with Splenocytes from Multiple Low-Dose Streptozotocin Diabetic Donors Experimental Biology and Medicine, November 1, 2001; 226(10): 898 - 905. [Abstract] [Full Text] [PDF]

				J. Verdaguer2, A. Amrani2, B. Anderson, D. Schmidt, and P. Santamaria Two Mechanisms for the Non-MHC-Linked Resistance to Spontaneous Autoimmunity J. Immunol., April 15, 1999; 162(8): 4614 - 4626. [Abstract] [Full Text] [PDF]

				A. A. ROSSINI, D. L. GREINER, and J. P. MORDES Induction of Immunologic Tolerance for Transplantation Physiol Rev, January 1, 1999; 79(1): 99 - 141. [Abstract] [Full Text] [PDF]

				F. Bridoux, A. Badou, A. Saoudi, I. Bernard, E. Druet, R. Pasquier, P. Druet, and L. Pelletier Transforming Growth Factor beta  (TGF-beta )-dependent Inhibition of T Helper Cell 2 (Th2)-induced Autoimmunity by Self-Major Histocompatibility Complex (MHC) Class II-specific, Regulatory CD4+ T Cell Lines J. Exp. Med., May 19, 1997; 185(10): 1769 - 1775. [Abstract] [Full Text] [PDF]