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Diabetes, Vol 38, Issue 5 558-561, Copyright © 1989 by American Diabetes Association

ARTICLES

Inhibition of streptozocin-induced insulitis and diabetes with lobenzarit in CD-1 mice

R Iwakiri and S Nagafuchi
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

When multiple low doses (30 mg/kg body wt) of streptozocin were given to CD-1 mice, diabetes associated with L3T4 T-lymphocyte- and B-lymphocyte-predominant insulitis occurred. Thus, a model of type I (insulin-dependent) diabetes was obtained. To treat these diabetic mice, we administered lobenzarit (CCA), a newly synthesized immunomodulator. CCA (2 or 10 mg/kg body wt) significantly inhibited the progression of diabetes by suppressing the severity and incidence of insulitis. Insulin contents of the pancreas were preserved. The possibility that autoimmune-related diabetes can be treated with CCA warrants further attention.
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S. Kondo, I. Iwata, K. Anzai, T. Akashi, S. Wakana, K. Ohkubo, H. Katsuta, J. Ono, T. Watanabe, Y. Niho, et al.
Suppression of insulitis and diabetes in B cell-deficient mice treated with streptozocin: B cells are essential for the TCR clonotype spreading of islet-infiltrating T cells
Int. Immunol., July 1, 2000; 12(7): 1075 - 1083.
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Copyright © 1989 by the American Diabetes Association.