Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rossetti, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rossetti, L.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 38, Issue 5 648-652, Copyright © 1989 by American Diabetes Association

ARTICLES

Normalization of insulin sensitivity with lithium in diabetic rats

L Rossetti
Diabetes/Endocrinology Division, Yale University School of Medicine, New Haven, Connecticut.

Lithium salts are commonly used in psychiatric patients and have been shown to have an insulinlike action in vitro. To define the impact of lithium ion on in vivo glucose metabolism, the effect of 2 wk of lithium treatment on plasma glucose and insulin concentrations, insulin-mediated glucose disposal, and skeletal muscle glycogen synthesis in normal and diabetic rats was examined. Our results demonstrated the ability of lithium ions to completely restore insulin sensitivity to normal in diabetic rats. The insulin-mimetic activity of the cation seems to be highly specific for the glycogenic pathway in skeletal muscle. These results raise the possibility that lithium ion may prove effective in reversing the defect in glycogen storage that characterizes non-insulin-dependent diabetes mellitus in humans.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
D. B. Ring, K. W. Johnson, E. J. Henriksen, J. M. Nuss, D. Goff, T. R. Kinnick, S. T. Ma, J. W. Reeder, I. Samuels, T. Slabiak, et al.
Selective Glycogen Synthase Kinase 3 Inhibitors Potentiate Insulin Activation of Glucose Transport and Utilization In Vitro and In Vivo
Diabetes, March 1, 2003; 52(3): 588 - 595.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M.-D. Chen, V. C. Yang, P. S. Alexander, P.-Y. Lin, and Y.-M. Song
Effects of Selected Minerals on Leptin Secretion in Streptozotocin-Induced Hyperglycemic Mice
Experimental Biology and Medicine, October 1, 2001; 226(9): 836 - 840.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
X. Chen, E. G. McMahon, and E. A. Gulve
Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1
Am J Physiol Endocrinol Metab, August 1, 1998; 275(2): E272 - E277.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Van Epps-Fung, K. Gupta, R. W. Hardy, and A. Wells
A Role for Phospholipase C Activity in GLUT4-Mediated Glucose Transport
Endocrinology, December 1, 1997; 138(12): 5170 - 5175.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. J. Orena, A. J. Torchia, and R. S. Garofalo
Inhibition of Glycogen-synthase Kinase 3 Stimulates Glycogen Synthase and Glucose Transport by Distinct Mechanisms in 3T3-L1 Adipocytes
J. Biol. Chem., May 19, 2000; 275(21): 15765 - 15772.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1989 by the American Diabetes Association.