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Diabetes, Vol 38, Issue 6 718-722, Copyright © 1989 by American Diabetes Association

ARTICLES

Cross-reactivity of anti-ssDNA antibodies with heparan sulfate in patients with type I diabetes mellitus

G Triolo, E Giardina, G Scarantino, G Seddio, F Cardella, F Meli and G Bompiani
Istituto di Clinica Medica I and Istituto di Clinica Pediatrica, University of Palermo, Italy.

Anti-single-stranded-DNA antibodies cross-reactive with heparan sulfate were detected in serums of patients with type I (insulin-dependent) diabetes mellitus. The results suggested that heparan sulfate, the major glycosaminoglycan constituent of the glomerular basement membrane, may serve as a target antigen in vivo for cross-reactive anti-DNA antibodies. These polyreactive antibodies, directed toward repeating negatively charged units, may neutralize the heparan sulfate-associated polyanionic sites in the glomerulus, leading to an abnormal permeability of anionic plasma proteins.
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Copyright © 1989 by the American Diabetes Association.