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Diabetes, Vol 38, Issue 7 942-945, Copyright © 1989 by American Diabetes Association

ARTICLES

Primary association of HLA-DQw8 with type I diabetes in DR4 patients

D Owerbach, S Gunn and KH Gabbay
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030.

DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain reaction technique for HLA-DR4 and the associated Dw and DQB subtypes of DR4. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Dw subtypes of DR4 other than DW10 did not confer additional association with type I diabetes. Thus, the DQ region appears to provide the primary major histocompatibility association with type I diabetes in most DR4 patients.
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Copyright © 1989 by the American Diabetes Association.