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Diabetes, Vol 38, Issue 9 1114-1116, Copyright © 1989 by American Diabetes Association

ARTICLES

High-dose porcine galanin infusion and effect on intravenous glucose tolerance in humans

SG Gilbey, J Stephenson, DJ O'Halloran, JM Burrin and SR Bloom
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.

The neuropeptide galanin inhibits glucose-stimulated insulin release in dogs and rodents and has been proposed as having a role in the control of insulin release in humans. The effect of infused galanin on intravenous glucose tolerance in humans was investigated by giving an intravenous glucose tolerance test (0.5 g glucose/kg body wt) alone and with infusions of synthetic porcine galanin at high-dose levels (80 and 160 pmol.kg-1.min-1) to seven healthy male volunteers. The results showed no effect of galanin infusion on plasma glucose or serum insulin, although a rise in serum growth hormone even in the face of the intravenous glucose load confirmed the potent growth hormone-stimulating effect of galanin. These results suggest that caution should be exercised in extrapolating a physiological role for galanin in humans from the results of animal studies.
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B. Ahren, G. Pacini, D. Wynick, N. Wierup, and F. Sundler
Loss-of-Function Mutation of the Galanin Gene Is Associated with Perturbed Islet Function in Mice
Endocrinology, July 1, 2004; 145(7): 3190 - 3196.
[Abstract] [Full Text] [PDF]


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Copyright © 1989 by the American Diabetes Association.