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Diabetes, Vol 39, Issue 12 1584-1586, Copyright © 1990 by American Diabetes Association

ARTICLES

Effect of FK 506 on spontaneous diabetes in BB rats

N Murase, I Lieberman, MA Nalesnik, DH Mintz, S Todo, AL Drash and TE Starzl
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania.

From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, approximately 75% of the rats that were diabetes free at 120 days remained so.
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A. Posselt, C. Barker, A. Friedman, and A Naji
Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth
Science, May 29, 1992; 256(5061): 1321 - 1324.
[Abstract] [PDF]


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Copyright © 1990 by the American Diabetes Association.