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Diabetes, Vol 39, Issue 3 397-399, Copyright © 1990 by American Diabetes Association

ARTICLES

Chronic exposure to high glucose and impairment of K(+)-channel function in perifused rat pancreatic islets

F Purrello, M Vetri, C Vinci, C Gatta, M Buscema and R Vigneri
Department of Endocrinology, University of Catania, Italy.

Prolonged exposure to high glucose levels impairs the ability of pancreatic islets to secrete insulin as a response to that stimulus. Because glucose, like other insulin secretagogues, elicits insulin secretion by inhibiting the ATP-sensitive K+ channels, in this study, we investigated the effect of prolonged (24-h) exposure of rat pancreatic islets to high (16.7 mM) glucose concentration on 86Rb efflux (used as a tracer for K+). The data obtained indicate that islets exposed to high glucose concentration have impaired function of the glucose-sensitive K+ channel, this phenomenon is temporarily related to a defective response of glucose-induced insulin release, and these alterations are reversible.
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W. Moritz, C. A. Leech, J. Ferrer, and J. F. Habener
Regulated Expression of Adenosine Triphosphate-Sensitive Potassium Channel Subunits in Pancreatic {beta}-Cells
Endocrinology, January 1, 2001; 142(1): 129 - 138.
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Copyright © 1990 by the American Diabetes Association.