Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jakobsen, J.
Right arrow Articles by Diemer, N. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jakobsen, J.
Right arrow Articles by Diemer, N. H.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 39, Issue 4 437-440, Copyright © 1990 by American Diabetes Association

ARTICLES

Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats

J Jakobsen, M Nedergaard, M Aarslew-Jensen and NH Diemer
Institute of Neuropathology, University of Copenhagen, Denmark.

Brain regional glucose metabolism and regional blood flow were measured from autoradiographs by the uptake of [3H]-2-deoxy-D-glucose and [14C]iodoantipyrine in streptozocin-induced diabetic (STZ-D) rats. After 2 days of diabetes, glucose metabolism in the neocortex, basal ganglia, and white matter increased by 34, 37, and 8%, respectively, whereas blood flow was unchanged. After 4 mo, glucose metabolism in the same three regions was decreased by 32, 43, and 60%. This reduction was paralleled by a statistically nonsignificant reduction in blood flow in neocortex and basal ganglia. It is suggested that the decrease of brain glucose metabolism in STZ-D reflects increased ketone body oxidation and reduction of electrochemical work.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 NeurologyHome page
A. M. Abbatecola, M. R. Rizzo, M. Barbieri, R. Grella, A. Arciello, M. T. Laieta, R. Acampora, N. Passariello, F. Cacciapuoti, and G. Paolisso
Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics.
Neurology, July 25, 2006; 67(2): 235 - 240.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
C. M. Ryan, M. I. Freed, J. A. Rood, A. R. Cobitz, B. R. Waterhouse, and M. W.J. Strachan
Improving Metabolic Control Leads to Better Working Memory in Adults With Type 2 Diabetes
Diabetes Care, February 1, 2006; 29(2): 345 - 351.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
E. R. Seaquist, G. S. Damberg, I. Tkac, and R. Gruetter
The Effect of Insulin on In Vivo Cerebral Glucose Concentrations and Rates of Glucose Transport/Metabolism in Humans
Diabetes, October 1, 2001; 50(10): 2203 - 2209.
[Abstract] [Full Text]

Home page
 BrainHome page
G.-J. Biessels, N. A. Cristino, G.-J. Rutten, F. P. T. Hamers, D. W. Erkelens, and W. H. Gispen
Neurophysiological changes in the central and peripheral nervous system of streptozotocin-diabetic rats: Course of development and effects of insulin treatment
Brain, April 1, 1999; 122(4): 757 - 768.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. J. Cipolla, J. M. Porter, G. Osol, and W. G. Mayhan
High Glucose Concentrations Dilate Cerebral Arteries and Diminish Myogenic Tone Through an Endothelial Mechanism
Stroke, February 1, 1997; 28(2): 405 - 411.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1990 by the American Diabetes Association.